Design and Synthesis of a Novel NIR Celecoxib-Based Fluorescent Probe for Cyclooxygenase-2 Targeted Bioimaging in Tumor Cells
Cyclooxygenase-2 (COX-2) imaging agents are potent tools for early cancer diagnosis.Almost all of the COX2 imaging agents using celecoxib as backbone were chemically modified in the position of N-atom in the sulfonamide group.Herein, a novel COX-2 probe (CCY-5) with high targeting Water Tank Assembly ability and a near-infrared wavelength (achieved